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SECOND CYCLE - MASTER'S DEGREE
THE GRADUATE SCHOOL OF HEALTH SCIENCES
MEDICAL BIOLOGY DEPARTMENT
3901 MEDICAL BIOLOGY PhD
Course Information
Course Learning Outcomes
Course's Contribution To Program
ECTS Workload
Course Details
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COURSE INFORMATION
Course Code
Course Title
L+P Hour
Semester
ECTS
TBI 614
DNA DAMAGE AND REPAIR MECHANISMS
2 + 0
2nd Semester
5
COURSE DESCRIPTION
Course Level
Master's Degree
Course Type
Elective
Course Objective
The aim of the lecture to understand knowledge of the mechanisms of DNA damage and repair At the end of this lecture, students are expected to have knowledge of mechanisms genomis DNA damage, oxidative stress and free radicals and the molecular mechanisms of the DNA repair in prokaryotic and eukaryotic organisms at PhD level and competence to analyze the knowledge at research area .
Course Content
Oxidative stres and free Radicals: Free radical formation in biological systems, The toxixity of Oxygen, free radical formation with ionise radiation Oxidative DNA damage: The types of DNA damage, interactions of free radicals with DNA DNA repair: Photoreactivation, adaptive response Nucleotide Excision: 3-methyladenin-DNA glycosylase, urasil-DNA glycosylase, Hydroxymethyluracil-DNA glycosylase, Hypoxanthine-DNA glycosylase, 5-mrthylcytosine-DNA glycosylase. Repair synthesis and DNA ligase .
Prerequisites
No the prerequisite of lesson.
Corequisite
No the corequisite of lesson.
Mode of Delivery
Face to Face
COURSE LEARNING OUTCOMES
1
Define fundamental principles and mechanisms that involve in DNA repair
2
Explain the importance of recombination in the replication of damaged DNA and the functions of DNA repair proteins
COURSE'S CONTRIBUTION TO PROGRAM
PO 01
PO 02
PO 03
PO 04
PO 05
PO 06
PO 07
PO 08
PO 09
PO 10
PO 11
PO 12
LO 001
5
5
4
4
5
4
3
3
4
4
4
LO 002
5
5
4
4
5
4
3
3
4
4
4
Sub Total
10
10
8
8
10
8
6
6
8
8
8
Contribution
5
5
4
4
0
5
4
3
3
4
4
4
ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION
Activities
Quantity
Duration (Hour)
Total Work Load (Hour)
Course Duration (14 weeks/theoric+practical)
14
2
28
Hours for off-the-classroom study (Pre-study, practice)
14
2
28
Mid-terms
1
30
30
Final examination
1
44
44
Total Work Load
ECTS Credit of the Course
130
5
COURSE DETAILS
Select Year
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2023-2024 Spring
2022-2023 Fall
2017-2018 Spring
2017-2018 Fall
2016-2017 Spring
2016-2017 Fall
2015-2016 Spring
2015-2016 Fall
2014-2015 Spring
2014-2015 Fall
2012-2013 Fall
2011-2012 Fall
2010-2011 Spring
Course Term
No
Instructors
Details
2023-2024 Spring
1
AYŞE GAYE TOMATIR
Details
2022-2023 Fall
1
AYŞE GAYE TOMATIR
Details
2015-2016 Spring
1
HAKAN AKÇA
Details
2014-2015 Spring
1
HAKAN AKÇA
Details
2012-2013 Fall
1
HAKAN AKÇA
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Course Details
Course Code
Course Title
L+P Hour
Course Code
Language Of Instruction
Course Semester
TBI 614
DNA DAMAGE AND REPAIR MECHANISMS
2 + 0
1
Turkish
2023-2024 Spring
Course Coordinator
E-Mail
Phone Number
Course Location
Attendance
Prof. Dr. AYŞE GAYE TOMATIR
tomatir@pau.edu.tr
KKM A0305-04
%70
Goals
The aim of the lecture to understand knowledge of the mechanisms of DNA damage and repair At the end of this lecture, students are expected to have knowledge of mechanisms genomis DNA damage, oxidative stress and free radicals and the molecular mechanisms of the DNA repair in prokaryotic and eukaryotic organisms at PhD level and competence to analyze the knowledge at research area .
Content
Oxidative stres and free Radicals: Free radical formation in biological systems, The toxixity of Oxygen, free radical formation with ionise radiation Oxidative DNA damage: The types of DNA damage, interactions of free radicals with DNA DNA repair: Photoreactivation, adaptive response Nucleotide Excision: 3-methyladenin-DNA glycosylase, urasil-DNA glycosylase, Hydroxymethyluracil-DNA glycosylase, Hypoxanthine-DNA glycosylase, 5-mrthylcytosine-DNA glycosylase. Repair synthesis and DNA ligase .
Topics
Weeks
Topics
1
x
2
x
3
x
4
x
5
x
6
x
7
x
8
x
9
x
10
x
11
x
12
x
13
x
14
x
Materials
Materials are not specified.
Resources
Course Assessment
Assesment Methods
Percentage (%)
Assesment Methods Title
Final Exam
50
Final Exam
Midterm Exam
50
Midterm Exam
L+P:
Lecture and Practice
PQ:
Program Learning Outcomes
LO:
Course Learning Outcomes
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Home Page
About University
Name And Address
Acedemic Authorities
General Discription
Academic Calendar
General Admission Requirements
Recognition of Prior Learning
General Registration Procedures
ECTS Credit Allocation
Academic Guidance
Information For Students
Cost Of Living
Accommodation
Meals
Medical Facilities
Facilities for Special Needs Students
Insurance
Financial Support for Students
Student Affairs
Learning Facilities
International Programs
Language Courses
Internships
Sports Facilities and Leisure Activities
Student Associations
Practical Information for Mobile Students
Degree Programmes