PAÜ .:. Eğitim Öğretim Bilgi Sistemi

COURSE INFORMATION

Course Code	Course Title	L+P Hour	Semester	ECTS
TBI 614	DNA DAMAGE AND REPAIR MECHANISMS	2 + 0	2nd Semester	5

COURSE DESCRIPTION

Course Level	Doctorate Degree
Course Type	Elective
Course Objective	The aim of the lecture to understand knowledge of the mechanisms of DNA damage and repair At the end of this lecture, students are expected to have knowledge of mechanisms genomis DNA damage, oxidative stress and free radicals and the molecular mechanisms of the DNA repair in prokaryotic and eukaryotic organisms at PhD level and competence to analyze the knowledge at research area .
Course Content	Oxidative stres and free Radicals: Free radical formation in biological systems, The toxixity of Oxygen, free radical formation with ionise radiation Oxidative DNA damage: The types of DNA damage, interactions of free radicals with DNA DNA repair: Photoreactivation, adaptive response Nucleotide Excision: 3-methyladenin-DNA glycosylase, urasil-DNA glycosylase, Hydroxymethyluracil-DNA glycosylase, Hypoxanthine-DNA glycosylase, 5-mrthylcytosine-DNA glycosylase. Repair synthesis and DNA ligase .
Prerequisites	No the prerequisite of lesson.
Corequisite	No the corequisite of lesson.
Mode of Delivery	Face to Face

COURSE LEARNING OUTCOMES

1	Define fundamental principles and mechanisms that involve in DNA repair
2	Explain the importance of recombination in the replication of damaged DNA and the functions of DNA repair proteins

COURSE'S CONTRIBUTION TO PROGRAM

	PO 01	PO 02	PO 03	PO 04	PO 05	PO 06	PO 07	PO 08	PO 09	PO 10	PO 11	PO 12
LO 001	5	5	4	4		5	4	3	3	4	4	4
LO 002	5	5	4	4		5	4	3	3	4	4	4
Sub Total	10	10	8	8		10	8	6	6	8	8	8
Contribution	5	5	4	4	0	5	4	3	3	4	4	4

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION

Activities	Quantity	Duration (Hour)	Total Work Load (Hour)
Course Duration (14 weeks/theoric+practical)	14	2	28
Hours for off-the-classroom study (Pre-study, practice)	14	2	28
Mid-terms	1	30	30
Final examination	1	44	44
Total Work Load ECTS Credit of the Course			130 5

COURSE DETAILS

Select Year

Course Details

Course Code	Course Title	L+P Hour	Course Code	Language Of Instruction	Course Semester
TBI 614	DNA DAMAGE AND REPAIR MECHANISMS	2 + 0	1	Turkish	2023-2024 Spring

Course Coordinator	E-Mail	Phone Number	Course Location	Attendance
Prof. Dr. AYŞE GAYE TOMATIR	tomatir@pau.edu.tr		KKM A0305-04	%70

Goals		The aim of the lecture to understand knowledge of the mechanisms of DNA damage and repair At the end of this lecture, students are expected to have knowledge of mechanisms genomis DNA damage, oxidative stress and free radicals and the molecular mechanisms of the DNA repair in prokaryotic and eukaryotic organisms at PhD level and competence to analyze the knowledge at research area .
Content		Oxidative stres and free Radicals: Free radical formation in biological systems, The toxixity of Oxygen, free radical formation with ionise radiation Oxidative DNA damage: The types of DNA damage, interactions of free radicals with DNA DNA repair: Photoreactivation, adaptive response Nucleotide Excision: 3-methyladenin-DNA glycosylase, urasil-DNA glycosylase, Hydroxymethyluracil-DNA glycosylase, Hypoxanthine-DNA glycosylase, 5-mrthylcytosine-DNA glycosylase. Repair synthesis and DNA ligase .

Topics

Materials

Materials are not specified.

Resources

Course Assessment

Assesment Methods	Percentage (%)	Assesment Methods Title
Final Exam	50	Final Exam
Midterm Exam	50	Midterm Exam

L+P: Lecture and Practice
PQ: Program Learning Outcomes
LO: Course Learning Outcomes

Prospective Student