PAÜ .:. Eğitim Öğretim Bilgi Sistemi

COURSE INFORMATION

Course Code	Course Title	L+P Hour	Semester	ECTS
BIO 514	BIOCHEMICAL TOXICOLOGY	3 + 0	1st Semester	7,5

COURSE DESCRIPTION

Course Level	Master's Degree
Course Type	Elective
Course Objective	This course examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. It reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.
Course Content	Introduction: Definition and Scope, Markers of toxicity, Metabolism of xenobiotics I, Metabolism of xenobiotics II, Metabolism of xenobiotics III, Protective systems against toxicity I, Protective systems against toxicity II, Reactive oxygen species I, Reactive oxygen species II, Induction of metabolism by toxicants, Toxic effects of inorganic salts, Toxic effects of pesticides, Toxic effects of hydrocarbons and alcohols, Toxic Effect of foods.
Prerequisites	No the prerequisite of lesson.
Corequisite	No the corequisite of lesson.
Mode of Delivery	Face to Face

COURSE LEARNING OUTCOMES

1	Will be able to know toxicity markers
2	Will be able to know xenobiotics metabolism
3	Will be able to know ROS
4	Will be able to know toxic effect of foods
5	Will be able to know protective systems against toxicity
6	Will be able to know how tok şive healthy

COURSE'S CONTRIBUTION TO PROGRAM

	PO 01	PO 02	PO 03	PO 04	PO 05	PO 06	PO 07	PO 08	PO 09	PO 10	PO 11
LO 001	4	5	4				4	4	4
LO 002	3	4	5	3
LO 003	3	3	4	4		4	5	3	5
LO 004	4	4	5	5
LO 005		4	5	5
LO 006		4	5	4
Sub Total	14	24	28	21		4	9	7	9
Contribution	2	4	5	4	0	1	2	1	2	0	0

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION

Activities	Quantity	Duration (Hour)	Total Work Load (Hour)
Course Duration (14 weeks/theoric+practical)	14	3	42
Hours for off-the-classroom study (Pre-study, practice)	14	7	98
Assignments	1	5	5
Mid-terms	1	15	15
Final examination	1	35	35
Total Work Load ECTS Credit of the Course			195 7,5

COURSE DETAILS

Select Year

	Course Term	No	Instructors
Details	2023-2024 Fall	1	ŞEVKİ ARSLAN
Details	2017-2018 Fall	1	ALAATTİN ŞEN

Course Details

Course Code	Course Title	L+P Hour	Course Code	Language Of Instruction	Course Semester
BIO 514	BIOCHEMICAL TOXICOLOGY	3 + 0	1	Turkish	2023-2024 Fall

Course Coordinator	E-Mail	Phone Number	Course Location	Attendance
Prof. Dr. ŞEVKİ ARSLAN	sevkia@pau.edu.tr		İTBF BB111	%85

Goals		This course examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. It reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.
Content		Introduction: Definition and Scope, Markers of toxicity, Metabolism of xenobiotics I, Metabolism of xenobiotics II, Metabolism of xenobiotics III, Protective systems against toxicity I, Protective systems against toxicity II, Reactive oxygen species I, Reactive oxygen species II, Induction of metabolism by toxicants, Toxic effects of inorganic salts, Toxic effects of pesticides, Toxic effects of hydrocarbons and alcohols, Toxic Effect of foods.

Topics

Weeks	Topics
1	Introduction
2	Dose-Response Relationships I
3	Dose-Response Relationships II
4	Factors Affecting Toxic Responses: Disposition
5	Factors Affecting Toxic Responses: Metabolism I
6	Factors Affecting Toxic Responses: Metabolism II
7	Factors Affecting Toxic Responses: Metabolism III
8	Factors Affecting Toxic Responses: Metabolism IV
9	Factors Affecting Disposition
10	Factors Affecting Metabolism I - Chemical Factors
11	Factors Affecting Metabolism II - Biological Factors
12	Specific Toxic Responses I - Teratogenesis
13	Specific Toxic Responses II - Genotoxicity
14	Specific Toxic Responses III - Chemical Carcinogenesis

Materials

Materials are not specified.

Resources

Course Assessment

Assesment Methods	Percentage (%)	Assesment Methods Title
Final Exam	50	Final Exam
Midterm Exam	50	Midterm Exam

L+P: Lecture and Practice
PQ: Program Learning Outcomes
LO: Course Learning Outcomes

Prospective Student