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COURSE INFORMATION
Course CodeCourse TitleL+P HourSemesterECTS
FAR 505PHARMACODYNAMICS3 + 01st Semester5

COURSE DESCRIPTION
Course Level Master's Degree
Course Type Elective
Course Objective Explain mechanisms involved in drug effects, drug-effect relationship,learning dose-effect relationship, putting forward various sinergistic and antagonistic drug effects.
Course Content Mechanisms of direct and indirect drug effect Dynamics of drug receptor interaction Dynamic of dose effect; time course of effect, dose effect, maximum effect, efficacy and variability Dynamics of agonistic drug effect Dynamics of antagonistic drug efffect Reversible and irreversible drug efffects Quantification of drug effects; Lineweaver-Burke, Scatchard analysis, Schild equation, Hill equation, Gaddum theory, Eadie–Hofstee plot Tolerance models Dynamic of drug and disease interaction Disease of ion channels and receptors Dynamic of drugs toxic effects Pharmacodynamic and pharmacokinetic interaction
Prerequisites No the prerequisite of lesson.
Corequisite No the corequisite of lesson.
Mode of Delivery Face to Face

COURSE LEARNING OUTCOMES
1Able to quantify and determine mechanisms underlying drug effects
2Able to define parameters involving in dynamics of dose effects
3Can explain dynamic, kinetic and disease interaction involved in drug effects
4Can explain mechanisms of drugs toxic effects

COURSE'S CONTRIBUTION TO PROGRAM
PO 01PO 02PO 03PO 04PO 05PO 06PO 07PO 08
LO 0015 55 4  
LO 0025 553433
LO 00352553524
LO 00454553524
Sub Total2062020918711
Contribution52552523

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION
ActivitiesQuantityDuration (Hour)Total Work Load (Hour)
Course Duration (14 weeks/theoric+practical)14342
Hours for off-the-classroom study (Pre-study, practice)5525
Mid-terms12626
Final examination13737
Total Work Load

ECTS Credit of the Course






130

5
COURSE DETAILS
 Select Year   


 Course TermNoInstructors
Details 2023-2024 Fall1MUHAMMED FATİH DOĞAN


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Course Details
Course Code Course Title L+P Hour Course Code Language Of Instruction Course Semester
FAR 505 PHARMACODYNAMICS 3 + 0 1 Turkish 2023-2024 Fall
Course Coordinator  E-Mail  Phone Number  Course Location Attendance
Assoc. Prof. Dr. MUHAMMED FATİH DOĞAN muhammedd@pau.edu.tr TIP C0110 %
Goals Explain mechanisms involved in drug effects, drug-effect relationship,learning dose-effect relationship, putting forward various sinergistic and antagonistic drug effects.
Content Mechanisms of direct and indirect drug effect Dynamics of drug receptor interaction Dynamic of dose effect; time course of effect, dose effect, maximum effect, efficacy and variability Dynamics of agonistic drug effect Dynamics of antagonistic drug efffect Reversible and irreversible drug efffects Quantification of drug effects; Lineweaver-Burke, Scatchard analysis, Schild equation, Hill equation, Gaddum theory, Eadie–Hofstee plot Tolerance models Dynamic of drug and disease interaction Disease of ion channels and receptors Dynamic of drugs toxic effects Pharmacodynamic and pharmacokinetic interaction
Topics
WeeksTopics
1 Mechanisms of direct and indirect drug effect
2 Dynamics of drug receptor interaction
3 Dynamic of dose effect; time course of effect, dose effect, maximum
4 Dynamics of agonistic drug effect
5 Dynamics of antagonistic drug effect
6 Reversible and irreversible drug efffects
7 Quantification of drug effects 1; Lineweaver-Burke, Scatchard analysis,
8 Quantification of drug effects 2; Schild Hill equation, Gaddum theory, Eadie–Hofstee
9 Tolerance models
10 Dynamics of drug and disease interaction
11 Disease of ion channels
12 Disease of receptors
13 Dynamics of drug toxic effect
14 Pharmacokinetic and pharmacodynamic interaction
Materials
Materials are not specified.
Resources
ResourcesResources Language
Rosenbaum S.E. Basic Pharmacokinetics and Pharmacodynamics. Jon Wiley&Sons, Inc.PublicatioNew Jersy, 2011. English
Kayaalp O. Akılcı Tedavi Yönünden Tıbbi Farmakoloji. 10. baskı. Ertem Basım Ltd.Şti. Ankara. 2012. Türkçe
Sodium-calcium Exchange, D.W.HILGEMANN, K.D.PHILIPSON, G.VASSORT , The newyork academy of sciences,1996 English
Hardman JG, Limbird LE. Goodman&Gilman’s The Pharmacological Basis of Therapeutics., 10th edition, The McGraw-Hill Companies, Inc. London.2001.English
Course Assessment
Assesment MethodsPercentage (%)Assesment Methods Title
Final Exam50Final Exam
Midterm Exam50Midterm Exam
L+P: Lecture and Practice
PQ: Program Learning Outcomes
LO: Course Learning Outcomes