PAÜ .:. Eğitim Öğretim Bilgi Sistemi

COURSE INFORMATION

Course Code	Course Title	L+P Hour	Semester	ECTS
FAR 501	PHARMACOKINETICS	3 + 0	1st Semester	5

COURSE DESCRIPTION

Course Level	Master's Degree
Course Type	Elective
Course Objective	Being acquainted with knowledge concerning drugs absorbtion, distribution, metabolism and excretion; consolidation of theoretical knowledge by scrutinizing and discussion of pharmacokinteics concepts, preparing the student for pharmacokinetic research phase by using pharmacokinetic formulas and theories based on clinical cases.
Course Content	Pharmacokinetic concepts; Compartment concepts; kinetic orders t1/2; Distribution; Clearance; Steady state Clinical cases; AUC; Dose-response relationship Bioavailability; Dose types Absorption kinetics Distribution kinetics Clearance and elimination kinetics Oxidative metabolism and Non-Oxidative metabolism Kinetic variability: Pharmacogenetics, Age Body weight, Pregnancy, Breast feeding Kinetic variability: Diseases, Renal dialysis Chronopharmacokinetics/ Dose individualization 1 Dose individualization 2
Prerequisites	No the prerequisite of lesson.
Corequisite	No the corequisite of lesson.
Mode of Delivery	Face to Face

COURSE LEARNING OUTCOMES

1	Provided with knowledge about factors changing drug absorbtion, distrubition, metabolism and excretion
2	Able to establish relationship between blood drug level and the dose
3	Ability to optimize drug dose in various clinical situations
4	Able to predict drug interactions and modify doses accordingly in multiple drug therapy

COURSE'S CONTRIBUTION TO PROGRAM

	PO 01	PO 02	PO 03	PO 04	PO 05	PO 06	PO 07	PO 08
LO 001	5	4	4	5	2	4	2	5
LO 002	5	5	4	5	2	4	2	4
LO 003	5	5	4	5	1	1	1	5
LO 004	5	4	5	5	1	4	2	5
Sub Total	20	18	17	20	6	13	7	19
Contribution	5	5	4	5	2	3	2	5

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION

Activities	Quantity	Duration (Hour)	Total Work Load (Hour)
Course Duration (14 weeks/theoric+practical)	14	3	42
Mid-terms	1	20	20
Final examination	1	38	38
Practice Professional Skills (Student)	2	15	30
Total Work Load ECTS Credit of the Course			130 5

COURSE DETAILS

Select Year

	Course Term	No	Instructors
Details	2019-2020 Fall	1	İZZETTİN HATİP

Course Details

Course Code	Course Title	L+P Hour	Course Code	Language Of Instruction	Course Semester
FAR 501	PHARMACOKINETICS	3 + 0	1	Turkish	2019-2020 Fall

Course Coordinator	E-Mail	Phone Number	Course Location	Attendance
			TIP C0107	%

Goals		Being acquainted with knowledge concerning drugs absorbtion, distribution, metabolism and excretion; consolidation of theoretical knowledge by scrutinizing and discussion of pharmacokinteics concepts, preparing the student for pharmacokinetic research phase by using pharmacokinetic formulas and theories based on clinical cases.
Content		Pharmacokinetic concepts; Compartment concepts; kinetic orders t1/2; Distribution; Clearance; Steady state Clinical cases; AUC; Dose-response relationship Bioavailability; Dose types Absorption kinetics Distribution kinetics Clearance and elimination kinetics Oxidative metabolism and Non-Oxidative metabolism Kinetic variability: Pharmacogenetics, Age Body weight, Pregnancy, Breast feeding Kinetic variability: Diseases, Renal dialysis Chronopharmacokinetics/ Dose individualization 1 Dose individualization 2

Topics

Weeks	Topics
1	Pharmacokinetic concepts; Compartment concepts;kinetic orders
2	Half life; Distribution; Clearance; Steady state
3	Clinical cases; AUC; Dose-response relationship
4	Bioavailability
5	Dose types and calculations
6	Absorption kinetics
7	Distribution kinetics
8	Clearance and elimination kinetics
9	Oxidative metabolism and Non-Oxidative metabolism
10	Kinetic variability: Pharmacogenetics, Age Body weight, Pregnancy, Breast feeding
11	Kinetic variability: Diseases, Renal dialysis
12	Chronokinetics
13	Dose individualization 1
14	Dose individualization 2

Materials

Materials are not specified.

Resources

Resources	Resources Language
İzzettin HATİP. Klinik ve Uygylamalı Farmakokinetik.. 1. Baskı. Nobel Tıp Kitabevi.İstanbul.2004	Türkçe
Rosenbaum S.E. Basic Pharmacokinetics and Pharmacodynamics. Jon Wiley&Sons, Inc NJ. 2011	English
İzzettin HATİP. Klinik ve Uygylamalı Farmakokinetik.. 1. Baskı. Nobel Tıp Kitabevi.İstanbul.2004	Türkçe
Rosenbaum S.E. Basic Pharmacokinetics and Pharmacodynamics. Jon Wiley&Sons, Inc NJ. 2011	English

Course Assessment

Assesment Methods	Percentage (%)	Assesment Methods Title
Final Exam	50	Final Exam
Midterm Exam	50	Midterm Exam

L+P: Lecture and Practice
PQ: Program Learning Outcomes
LO: Course Learning Outcomes

Prospective Student