Course Objective |
The study of genetics is one of the most rapidly advancing and exciting areas in biology and medicine today. During the course, students learn fundamental principles of eukaryotic and prokaryotic genetics. The course discusses studies of Mendel and how Mendelian genetics can be used in genetic analysis of human genetic diseases. During the course, extensions to Mendelian genetics, gene linkage, and recombination is covered in detail. At the end of the course, students will be able to analyze problems related to the field of genetics based on their course training. |
Course Content
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Introduction of Genetics: History and historical development of genetics, Chromosome theory of inheritance: genetic material, gen and chromosome, cell cycle (mitosis ve meiosis), chromosomes theory of heredity and problem solving with the related topics. Mendel Genetics: Mendel Laws, chi-square test and pedigree Extensions of Mendelian Analysis:Variation on dominance (codominance and incomplete dominance), various genes affecting the same character (epistasi), pleitropi, multiple alleles, lethal alleles, sex chromosomes and sex linkage, sex limited inheritance and environmental effect on genetics Linkage:The discovery of linkage, recombination, linkage maps, three-point test cross, interference, examples of linkage maps, nature of crossing-over. Tetrad analysis, mitotic recombination and segregation. The structure of DNA: DNA genetic material, the structure of DNA, replication of DNA, mechanism of DNA replication, DNA replication in eukaryotes, DNA and gene. DNA function:Transcription, translation, genetik code, protein synthesis, universality of genetic information transfer, eukaryotic RNA, and mechanism of gene splicing. Control of gene expression:Prokaryotic gene expression, discovery of Lac operon (positive and negative control), and problem solving. Recombination in bacteria and their viruses: transfer mechanisms in bacteria: bacterial conjugation, bacterial recombination and mapping the E. coli chromosome, bacterial transformation, bacteriophage genetics, transduction, chromosome mapping, and bacterial gene transfer. The extranuclear genome:extranuclear inheritance in higher plants, extranuclear inheritance in fungi, shell coiling in snails, extranuclear gene in Chlamydomonas, mithochondrial genome, and chloroplast genome.
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